Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy

Serologic Investigations in Children with Inflammatory Bowel Disease and Food Allergy

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The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA.Patients and methods.The study comprised here 95 children at the ages of 2 to 18 years.The diagnosis of IBD was established on the basis of Porto criteria.Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method.

Results.IgE-dependent FA was found in 32.5% children with UC and in 21% with CD.We did not observe any relation between the occurrence of FA and the frequency and ASCA titre.p-ANCA were significantly more frequent in the group of children with UC.

The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis.Conclusions.Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age.

We observed a connection between the occurrence of antibodies and the pure energy jeans examined mutations of gene NOD2/CARD15.